Background:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.

Applications:

ELISA, IHC

Name of antibody:

TRIM23

Immunogen:

Fusion protein of human TRIM23

Full name:

tripartite motif containing 23

Synonyms:

ARD1; ARFD1; RNF46

SwissProt:

P36406

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human tonsil

IHC Recommend dilution:

35-200