Background:

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Applications:

ELISA, WB, IHC

Name of antibody:

RNASE1

Immunogen:

Fusion protein of human RNASE1

Full name:

ribonuclease A family member 1, pancreatic

Synonyms:

RAC1; RIB1; RNS1

SwissProt:

P07998

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

50-100

WB Predicted band size:

18 kDa

WB Positive control:

Rat pancreas tissue and Mouse pancreas tissue lysates

WB Recommended dilution:

500-2000