Background:

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Applications:

ELISA, WB, IHC

Name of antibody:

RRM1

Immunogen:

Fusion protein of human RRM1

Full name:

Ribonucleotide reductase M1

Synonyms：

R1; RR1; RIR1

SwissProt:

P23921

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

90 kDa

WB Positive control:

Hela and 231 cells

WB Recommended dilution:

200-1000