Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Applications:

WB, FC

Name of antibody:

TNFRSF4

Immunogen:

Fusion protein of human TNFRSF4

Full name:

TNF receptor superfamily member 4

Synonyms:

OX40; ACT35; CD134; IMD16; TXGP1L

SwissProt:

P43489

WB Predicted band size:

29 KD

WB Positive control:

PHA-PBMC cell lysate

WB Recommended dilution:

200-1000

FC Recommend dilution:

50-100