Background:

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

Applications:

ELISA, IHC

Name of antibody:

SDC2

Immunogen:

Synthetic peptide of human SDC2

Full name:

syndecan 2

Synonyms:

HSPG; CD362; HSPG1; SYND2

SwissProt:

P34741

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human brain

IHC Recommend dilution:

25-100